with rare side effects. If the deficiency is an isolated growth hormone deficiency 停车位被占怒砸车

Health Human growth hormone therapy (also called growth hormone, HGH, hGH, GH) is a naturally occurring hormone that is secreted by the anterior pituitary gland. Human growth hormone is produced by somatotropes in the pituitary gland of the human brain. Human growth hormone is a heterogenous mixture of polypeptides secreted by the anterior pituitary gland. The principal form of HGH is a polypeptide containing 191 amino acids with a molecular weight of 215,000 daltons. Recombinant human growth hormone (rHGH) is produced by cells that have been genetically engineered to make this hormone. Growth hormone is natural, it is plentiful in the human body during youth. Growth hormone levels decline rapidly after age 30. HGH is responsible for normal body growth and development by stimulating protein production in muscle cells and energy release from the breakdown of fats. Functions and health benefits of Human growth hormone therapy. GH is responsible for the regulation of insulin (glucose metabolism), protein synthesis, transportation of amino acids across cell membranes, growth factor-1 (a metabolic liver hormone) and IGF-2, osteoblast production (bone mass) and fat metabolism. HGH has been used to promote growth in prepubertal children who fail to make sufficient growth hormone and in adults with pituitary disease. Growth hormone increases calcium retention, and strengthens and increases the mineralization of bone. Growth hormone increases muscle mass, and induces protein synthesis and growth of many different organ systems of the body, resulting in a positive nitrogen balance. Growth hormone acts on fat cells to reduce the amount of stored fats, promotes protein synthesis in cells and plays a role in regulating the sugar levels in the blood. Human Growth hormone deficiency Deficiency of GH produces significantly different problems at various ages. Deficiency of growth hormone secretion before puberty results in pituitary dwarfism. Growth retardation may become evident in infancy and persist throughout childhood. The child’s "growth curve," which is usually plotted on a standardized growth chart by the pediatrician, may range from flat (no growth) to very shallow (minimal growth). Normal puberty may or may not occur, depending on the degree to which the pituitary can produce adequate hormone levels other than growth hormone. In adults the effects of deficiency are more subtle, and may include deficiencies of strength, energy, bone mass, and increased cardiovascular risk. Growth hormone deficiency involves abnormally short stature with normal body proportions. Growth hormone deficiency can be categorized as either congenital (present at birth) or acquired. An abnormally short height in childhood may occur if the pituitary gland does not produce enough growth hormone. It can be caused by a variety of genetic mutations (such as Pit-1 gene, Prop-1 gene, growth hormone receptor gene, growth hormone gene), absence of the pituitary gland, or severe brain injury, but in most cases no underlying cause of the deficiency is found. Acquired GH deficiency is characterized by weight gain, increased fat mass and decreased lean body mass. In one recent study, total body fat was shown to be increased by 7% in this population while lean body mass was decreased to a similar degree. Growth hormone excess An excess of growth hormone can lead to gigantism or acromegaly, both of which are characterized by a very large stature. Gigantism is the result of hGH overproduction in early childhood leading to a skeletal height up to 8 feet or more. Excess growth hormone produced after puberty has little effect on the growth of the skeleton, but it results in a disease affecting terminal skeletal structures known as acromegaly. Acromegaly results when hGH is overproduced after the onset of puberty. In this condition, the epiphyseal plates of the long bone of the body do not close, and they remain responsive to additional stimulated growth by hGH. This disorder is characterized by an enlarged skull, hands and feet, nose, neck, and tongue. The primary effect of growth hormone excess in childhood is excessive growth, but the tallness is accompanied by a characteristic body build recognizable to an endocrinologist. The typical body build involves heavy, thick bones, with large hands and feet and a heavy jaw. Once puberty is complete and adult height is achieved, continued thickening of the skin and growth of the jaw results in a combination of features referred to as acromegaly. Growth hormone treatment Once growth hormone deficiency has been diagnosed, treatment for the disorder involves regular injections of human growth hormone (some children receive daily injections, while others receive injections several times a week). Synthetic growth hormone can be used for children with growth hormone deficiency. This treatment requires the assistance of a pediatric endocrinologist. Treatment with synthetic (recombinant) human growth hormone is generally considered to be safe, with rare side effects. If the deficiency is an isolated growth hormone deficiency, synthetic growth hormone is given alone. If the deficiency is not isolated, other hormone replacement preparations will be required as well. When a person has had a long-standing deficiency of GH, benefits of treatment are often obvious, and side effects of treatment are rare. When treated with GH, a deficient child will begin to grow faster within months. Treatment usually lasts several years, although results are often seen as soon as three to four months after the injections are started. The earlier the treatment for growth hormone deficiency is started, the better chance the child will have of attaining normal or near-normal adult height. In August 1996, the FDA approved HGH for use in adult patients. Before this, it was authorized only for use to promote growth in HGH-deficient children. GH treatment can provide a number of measurable benefits to severely GH-deficient adults, such as enhanced energy and strength, and improved bone density. Muscle mass may increase at the expense of adipose tissue. As of 2004, GH has been approved by the U.S. Food and Drug Administration for treatment of Turner syndrome, chronic renal failure, Prader-Willi syndrome, and idiopathic short stature. About the Author: 相关的主题文章:

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